Study on effect of pH on rectum permeability of active ingredients in Reduning suppositories in vitro.
- Author:
Ming YAN
;
Ying-chun WEI
;
Jin MENG
;
Dian-hong XU
;
Yun WU
;
Wei XIAO
- Publication Type:Journal Article
- MeSH: Animals; Chlorogenic Acid; pharmacokinetics; Drugs, Chinese Herbal; pharmacokinetics; Hydrogen-Ion Concentration; Iridoids; pharmacokinetics; Male; Permeability; Rats; Rats, Sprague-Dawley; Rectum; metabolism; Suppositories; pharmacokinetics
- From: China Journal of Chinese Materia Medica 2015;40(8):1493-1496
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effect of different pH on rectum permeability of chlorogenic acid and geniposide.
METHODFour kinds of Reduning suppositories of different pH were separated and put into the rectum to study the suppositories in vitro and the content of chlorogenic acid and geniposide samples was determined by HPLC to calculate the permeation in 24 hours.
RESULTWith increase of pH within 2.5-7.4, the steady state flux of chlorogenic acid was increased, but the steady state flux of geniposidesamples was steady.
CONCLUSIONAdjusted the pH can increase the rectum permeability of active ingredients in Reduning auppositories.