Triterpenes from herb of Potentilla chinesis.
- Author:
Pu LIU
1
;
Hong-quan DUAN
;
Qin PAN
;
Yan-wen ZHANG
;
Zhi YAO
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Antineoplastic Agents, Phytogenic; chemistry; isolation & purification; pharmacology; Cell Line; Cell Survival; drug effects; Chromatography, High Pressure Liquid; Fibroblasts; cytology; drug effects; HeLa Cells; Humans; Mice; Molecular Structure; Plants, Medicinal; chemistry; Potentilla; chemistry; Triterpenes; chemistry; isolation & purification; pharmacology
- From: China Journal of Chinese Materia Medica 2006;31(22):1875-1879
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the chemical constituents of Potentilla chinesis and their anticancer activities.
METHODChemical constituents were isolated by repeated column chromatography (Toyopearl HW-40C and preparative HPLC). The structures were elucidated on the basis of spectral data analysis. The isolated compounds were screened with two anticancer models.
RESULTFifteen triterpenes, alpha-amyrin (1) , beta-amyrin (2) , ursolic acid (3) , corosolic acid (4), euscaphic acid (5) , pomolic acid (6) , tormentic acid (7), 2alpha, 3alpha-dihydroxyurs-12-en-28-oic acid (8), 2beta, 3beta, 19alpha-trihydroxyurs-12-en-28-oic acid (9), asiatic acid (10) , 24-hydroxy tormentic acid (11) , myrianthic acid (12), oleanolic acid (13), maslinic acid (14) and 2alpha, 3alpha-dihydroxyolean-12-en-28-oic acid (15) , were isolated from P. chinesis.
CONCLUSIONCompounds 1, 2, 4 -15 were isolated from the plant for the first time. Compounds 4, 8 - 10, 12, 14 and 15 show anticancer activities. Compounds 4, 9 show strong activities.
