Effect of Fuzheng Jiangan formula on liver fibrosis induced by albumin in rats.
- Author:
Xiang-an HUANG
1
;
Li-hong SUN
;
Chong-shun SONG
;
Ning CUI
;
Yan-li CHEN
;
Hong-yan XU
;
Ying REN
Author Information
- Publication Type:Journal Article
- MeSH: Alanine Transaminase; blood; Animals; Aspartate Aminotransferases; blood; Collagen Type IV; blood; Drugs, Chinese Herbal; pharmacology; Humans; Hyaluronic Acid; blood; Hydroxyproline; metabolism; Laminin; blood; Liver; drug effects; metabolism; pathology; Liver Cirrhosis, Experimental; blood; chemically induced; prevention & control; Male; Plants, Medicinal; chemistry; Random Allocation; Rats; Rats, Wistar; Serum Albumin
- From: China Journal of Chinese Materia Medica 2006;31(22):1890-1893
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the effect of Fuzheng Jiangan formula( FZJGF) on liver fibrosis using immune induced liver fibrosis rat model.
METHODThe rat models with immunity liver fibrosis were induced by the human serum albumin. Rats were treated with normal saline, FZJGF (9. 85,39. 4 g x kg(-1) , two dosage groups) and Colchicine (0. 000 1 g . kg(-1) ). The activities of ALT, AST, contents of ALB and TP, and A/G, The contents of Laminin (LN), Hyaluronic acid (HA) and collagen type IV (IV-C) in rat serum were measured by radioimmunoassay method. The level of hydroxyproline (Hyp) in liver was detected by chemistry method. The pathological changes of liver tissue were observed by HE and Von-Gieson staining.
RESULTFZJGF could significant decrease the serum activities of ALT and AST, and increase the levels of TP,Alb and ratio A/G. The levels of LN, HA and IV-C were decreased significantly after the treatment using FZJGF. The pathological improvements were observed. FZJGF could markedly alleviate the deposition of collageneous fiber, and reduce the liver pseudoluboli and the fibrosis scores in the liver tissue compared with model group.
CONCLUSIONFZJGF can inhibit formation and development of rat hepatic fibrosis induced by the human serum albumin.
