Studies on using spray drying technique in preparing Ophiopogon japonicus saponin enteric microsphere by orthogonal experimental design.
- Author:
Lan SHEN
1
;
Yi FENG
;
De-sheng XU
;
Xiao LIN
Author Information
- Publication Type:Journal Article
- MeSH: Drug Compounding; methods; Microscopy, Electron; Microspheres; Ophiopogon; chemistry; Plants, Medicinal; chemistry; Saponins; chemistry; isolation & purification; Tablets, Enteric-Coated; chemistry; Temperature
- From: China Journal of Chinese Materia Medica 2006;31(23):1947-1950
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the best technique parameters on preparing ophiopogon japonicus saponin enteric microsphere by spray drying technique.
METHODThe best technique parameters were investigated by orthogonal experimental design and by the target, such as surface appearances, encapsulated efficiency, etc.
RESULTThe best technique parameters included the inlet temperature (90 degrees C ), the feeding speed (10 mL x min(- 1)), and the rotate speed of atomizer (50 r x min(-1)).
CONCLUSIONOphiopogon japonicus saponin enteric microsphere accorded with the expecting demand. The main influencing factor was inlet temperature . It is suitable to industrialize in preparing Traditional Chinese Medicine microsphere.
