Studies on diterpenes in needles of Pinus sylvestris.
- Author:
Rong ZHANG
1
;
Hong-quan DUAN
;
Zhi YAO
;
Qin PAN
;
Fu-geng ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Antineoplastic Agents, Phytogenic; chemistry; isolation & purification; pharmacology; Cell Line, Tumor; Cell Survival; drug effects; Chromatography, High Pressure Liquid; Diterpenes; chemistry; isolation & purification; pharmacology; Diterpenes, Abietane; chemistry; isolation & purification; pharmacology; HeLa Cells; Humans; Molecular Structure; Pinus sylvestris; chemistry; Plant Leaves; chemistry; Plants, Medicinal; chemistry; Structure-Activity Relationship
- From: China Journal of Chinese Materia Medica 2006;31(23):1956-1959
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo research the constituents in needles of Pinus sylvestris.
METHODRepeated column chromatography and preparation HPLC are used for compound isolation, and their structures were elucidated on the basis of spectral data analysis.
RESULTSix compounds, pinifolic acid (1), 15-oxo-8 (17) -labden-18-oic acid (2) , 15-acetoxy-labd-8 ( 17)-en-18-oic acid (3), dehydroabietic acid (4), 7alpha-hydroxydehydroabietic acid (5), 7beta-hydroxydehydroabietic acid (6) were isolated from the needles of P. sylvestris.
CONCLUSIONCompound 3-6 were isolated from the needles of P. sylvestris for the first time, and compound 3 is a new natural product. The petroleum ether and EtOAc extracts showed significant cytotoxic effects to Hela and A549. Compounds 2, 4-6 revealed a positive distinction compared to the control group.
