Studies on chemical constituents from leaves of Isatis indigotica.
- Author:
Ji-feng LIU
1
;
Xue-mei ZHANG
;
Duo-qing XUE
;
Zhi-yong JIANG
;
Qiong GU
;
Ji-jun CHEN
Author Information
- Publication Type:Journal Article
- MeSH: Furans; chemistry; isolation & purification; Indole Alkaloids; chemistry; isolation & purification; Isatis; chemistry; Lignans; chemistry; isolation & purification; Lignin; chemistry; isolation & purification; Naphthols; chemistry; isolation & purification; Plant Leaves; chemistry; Plants, Medicinal; chemistry; Quinolines; chemistry; isolation & purification
- From: China Journal of Chinese Materia Medica 2006;31(23):1961-1965
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the chemical constituents of the leaves of Isatis indigotica.
METHODThe leaves of I. indigotica were extracted with 80% ethanol. The EtOH extract was dispersed in H20 and extracted with petroleum, EtOAc and BuOH successively. The EtOAc fraction was isolated and purified by column chromatography on silica gel, Sephadex LH -20 and Rp-8, Rp-18. All the compounds were identified on the basis of spectral analyses (including MS, 1H-NMR, 13 C-NMR) , RESULT: Eleven compounds were isolated from the leaves of I. indigotica, and structures were characterized as 10H-indolo [3, 2-b] quinoline (1), indirubin (2), 4 (3H)-quinazo-linone (3), (E)-3-(3', 5'-dimethoxy-4'-hydroxybenzylidene) -2-indolinone (4), 2, 3-dihydropyrrolo [2, 1-b] quinazolin-9(1H) -one (5) , benzoic acid (6) , o-droxy-benzoic acid (7), ( - ) -lariciresinol (8) , ( + ) -isolariciresinol (9), isovitexin (10), 6-f-D-glucopyranosyldiosmetin (11).
CONCLUSION1, 4, 5, 8, 9, 11 were obtained from the leaves of I. indigotica for the first time.
