Safety issues of traditional Chinese medical preparations containing arsenic substances: review starting from Niuhuang Jiedu Pian (Wan).
- Author:
Li ZHANG
1
;
Si-Hua GAO
;
Chao-fan ZHOU
;
Rui-chao LIN
;
Chang-hua LIU
Author Information
1. Center or Drug reevaluation, State Food and Drug Administration, Beijing 100061, China.
- Publication Type:Journal Article
- MeSH:
Arsenic Poisoning;
history;
prevention & control;
Arsenicals;
adverse effects;
analysis;
history;
Drug Combinations;
History, 20th Century;
History, 21st Century;
History, Ancient;
History, Medieval;
Humans;
Medicine, Chinese Traditional;
Sulfides;
adverse effects;
analysis;
history
- From:
China Journal of Chinese Materia Medica
2006;31(23):2010-2013
- CountryChina
- Language:Chinese
-
Abstract:
By comprehensively reviewing the origin and history of Niuhuang Jiedu Wan and its "derivatives", we studied the clinical records of realgar, investigated its clinical usage, dosage, efficacy, and toxicity in the literatures. We pinpointed the factors that might be associated with safety problems of Niuhuang Jiedu Pian (Wan) and other traditional Chinese medicine (TCM) preparations containing arsenic substances. In this article we also put forward suggestions for strengthening the surveillance and administration of similar TCM preparations.
