Preparation of inclusion complex of daidzein and hydropropyl-beta-cyclodextrin.
- Author:
Yue-Bin GE
1
;
Da-Wei CHEN
;
Li-Ping XIE
;
Hong-Zhong WANG
;
Gui-Lan ZHENG
;
Rong-Qing ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: 2-Hydroxypropyl-beta-cyclodextrin; Differential Thermal Analysis; Drug Compounding; methods; Isoflavones; chemistry; Solubility; Spectroscopy, Fourier Transform Infrared; X-Ray Diffraction; beta-Cyclodextrins; chemistry
- From: China Journal of Chinese Materia Medica 2006;31(24):2039-2041
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo prepare an inclusion complex of daidzein and hydropropyl-beta-cyclodextrin to enhance the solubility of daidzein.
METHODThe inclusion complex of daidzein was prepared by the solution stirring method. The binary system of daidzein and HP-beta-CD was confirmed by differential thermal, thermogravimetry analysis, infrared spectroscopy and X-ray diffractometry.
RESULTThe drug content in the inclusion complex was 6. 76% and the solubility was 13.68 mg x mL(-1). The identification results showed that the inclusion complex was formed.
CONCLUSIONThe preparation method of the inclusion complex of daidzein and hydropropyl-beta-cyclodextrin is simple and available, with a increased solubility of daidzein.
