Norisoprenoids from red alga Gymnogongrus flabelliformis.
- Author:
Zhao-Hui YUAN
1
;
Li-Jun HAN
;
Xiao FAN
;
Shuai LI
;
Ming MA
;
Yong-Chun YANG
;
Jian-Gong SHI
Author Information
- Publication Type:Journal Article
- MeSH: Antineoplastic Agents; chemistry; isolation & purification; pharmacology; Butanols; chemistry; isolation & purification; pharmacology; Cell Line, Tumor; Cell Survival; drug effects; Chromatography, High Pressure Liquid; Cyclohexanones; chemistry; isolation & purification; pharmacology; Humans; Inhibitory Concentration 50; Magnetic Resonance Spectroscopy; Norisoprenoids; chemistry; isolation & purification; pharmacology; Rhodophyta; chemistry
- From: China Journal of Chinese Materia Medica 2006;31(24):2046-2048
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the chemical constituents of the red alga Gymnogongrus flabelliformis Harv.
METHODCompounds were isolated by normal phase silica gel and Sephadex LH - 20 gel column chromatography and reverse phase HPLC. Their structures were elucidated by spectroscopic methods including MS, 1H-NMR, 13C-NMR. Cytotoxicity of the compounds was screened by using standard MIT method.
RESULTFive compounds were isolated from G. flabelliforrmis, their structures were identified as(3S, 6R, 7E)-( + )-3-hydroxyl-4, 7-mega-stigmadien-9-one (1), (3S, 5R, 6S, 7E)-(-)-3-hydroxy-5, 6-epoxy-7-megastigmene-9-one (2), (3S, 5S, 6R, 7E)-(+)3-hydroxy-5, 6-epoxy-7-megastigmene-9-one (3), dehydrovomifoliol (4), (3R)-(-)4-[(2R, 4S)-4-acetoxy-2-hydroxy-2, 6, 6-trimethylcyclohexylidene] -3-buten-2-one (5).
CONCLUSIONAll of the compounds were obtained from this species for the first time and compound 1 was a new natural product. These compounds were inactive (IC50 > 10 microg x mL(-1)) in the MTT assay against several human cancer cell lines.
