Effect of Qianjin Fubao on changes of behavior and estradiol level in chronic stress model rats.
- Author:
Ying LI
1
;
Yong-Juan JI
;
Hai-Li SANG
;
Hong JIANG
;
Shu-Juan FAN
;
Teng-Teng WANG
;
Fang PAN
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Behavior, Animal; drug effects; Drug Combinations; Drugs, Chinese Herbal; isolation & purification; pharmacology; Estradiol; blood; Female; Plants, Medicinal; chemistry; Random Allocation; Rats; Rats, Wistar; Stress, Psychological; blood; physiopathology
- From: China Journal of Chinese Materia Medica 2006;31(24):2067-2070
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effect of Qianjin Fubao (QJFB) on behavior and estradiol level in femal chronic stress model rats.
METHODTwenty four female Wistar rats (2 month old) were evenly randomized into normal control, animal model and QJFB (0.7 g x kg(-1) x d(-1)) group. The QIFB group and the stress group were exposed to a chronic unpredictable stress for 21 days. Rats of the QJFB group received perfusion of Qianjin Fubao, and rats of stress and control group were perfused with normal saline. The behavior of three groups were determined with the method of Open-field before and after right stress respectively. Serum level of estradiol was detected with radioim munoassay.
RESULTThe behavioral score and the serum level of estradiol of the stressed group were significantly lower than those of the control group after stress (P < 0.05). There were no significant differences of behavioral score and the serum level of estradiol between QJFB group and control group.
CONCLUSIONThe chronic unpredictable stress can induce the stressful change of behavior, and QJFB may recover the rats'abnormal behavior and improve the serum level of estradiol. QJFB may have protective effect on stress.
