Blood lipid-regulation of stilbene glycoside from polygonum multiflorum.
- Author:
Xuan GAO
1
;
Ying-Jie HU
;
Lin-Chun FU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Anticholesteremic Agents; administration & dosage; pharmacology; Atorvastatin Calcium; Cholesterol, LDL; blood; Glucosides; administration & dosage; isolation & purification; pharmacology; Hepatocytes; cytology; drug effects; metabolism; Heptanoic Acids; administration & dosage; pharmacology; Hydroxymethylglutaryl CoA Reductases; biosynthesis; genetics; Hyperlipidemias; blood; prevention & control; Male; Plant Tubers; chemistry; Plants, Medicinal; chemistry; Polygonum; chemistry; Pyrroles; administration & dosage; pharmacology; RNA, Messenger; biosynthesis; genetics; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, LDL; biosynthesis; genetics; Stilbenes; administration & dosage; isolation & purification; pharmacology; Triglycerides; blood
- From: China Journal of Chinese Materia Medica 2007;32(4):323-326
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study lipid-regulating action of 2, 3, 5, 4'-tetrahydroxy stilbene-2-O-beta-D-glucopyranoside (TSG) from Polygonum multiflorum on experimental model hyperlipidemic rats.
METHODTSG 90 and 180 mg x kg(-10 x d(-1), atorvastatin mg kg(-1) x d(-1) and saline 2 mL x d(-1) were administered to hyperlipidemic rats. Groups of rats were determined and compared with those of saline group. The LDLR and HMGR mRNA expression were also detected.
RESULTTSG significantly reduced serum TC and LDL-C level and atherosclerosis index, increased the expression of LDLR in the liver cells.
CONCLUSIONTSG, which shows effects and mechanism in part like atorcastatin, is a major constituent with blood-lipid regulating effect of P. multiflorum and can be explored as a potent medication for hyperlipidemia. Effects on LDL-C and AI, as well as on gene expression of TSG were first reported.
