Preparation and evaluation of sustained-release microsphere of Sanguis Draconis in vitro.
- Author:
Li-Yu DING
1
;
Peng-Fei XIA
;
Cai-Qin YANG
;
Yu-Long LIN
;
Jing WANG
Author Information
- Publication Type:Journal Article
- MeSH: Arecaceae; chemistry; Delayed-Action Preparations; chemistry; Drugs, Chinese Herbal; chemistry; isolation & purification; Lactic Acid; chemistry; Microspheres; Particle Size; Plants, Medicinal; chemistry; Polyesters; Polymers; chemistry; Reproducibility of Results; Resins, Plant; chemistry; Technology, Pharmaceutical; methods
- From: China Journal of Chinese Materia Medica 2007;32(5):388-390
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo prepare sustained-release microsphere containing extract of Sanguis Draconis and to measure its dissolution in vitro.
METHODSustained-release microsphere was prepared with polylactic acid (PLA) as carriers using the oil-in-water (O/W) emulsion solvent evaporation method. The powder particle's characteristics of sustainded-release microsphere were evaluated comprehensively, and its dissolution characteristics in vitro were studied.
RESULTThe microsphere was round and its surface was smooth, drug-loading rate was 21.97% and the entrapment rate was 55.76%, the accumulative release percentage was 76. 71% in 16 hours.
CONCLUSIONThe sustained release effect of Sanguis Draconis microspheres was formed with potentially wide applications.
