Cyclin D1 gene G870A polymorphism and susceptibility to nasopharyngeal carcinoma
10.3760/cma.j.issn.1673-0860.2009.03.011
- VernacularTitle:细胞周期素D1 G870A基因多态性与鼻咽癌的相关性研究
- Author:
Jun SUI
1
;
Wei GAO
;
Xiao-Jiang LI
;
Jing MA
;
Yanxin REN
;
Xin SONG
;
Chunjie XIAO
;
Wenru TANG
Author Information
1. 昆明医学院附属第三医院
- Keywords:
Nasopharyngeal neoplasms;
Carcinoma,squamous cell;
Genes,bcl-1;
Polymorphism,single nucleotide;
Genetic predisposition to disease;
Prognosis
- From:
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
2009;44(3):227-231
- CountryChina
- Language:Chinese
-
Abstract:
Objective The aim of this study was to investigate the susceptibility and prognostic implications of the cyclin D1 gene(CCND1) G870A polymorphism to nasopharyngeal carcinomas (NPC) in Han population in Yunnan China. Methods Two hundred and forty one cases with NPC and 271 matched cancer-free controls were genotyped for the CCND1 G870A polymorphism by polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP) and sequencing. The adjusted odds ratios (OR) and 95% confidence intervals (CI) were calculated by using unconditional logistic regression model. Overall survival was assessed using univariate and multivariate analyses. Results Contrast with homozygous CCND1 G870G, A allele significantly increasing risk of NPC was associated with homozygous A870A (OR =4.79, 95% CI 2.77 - 8.28, P < 0.001) and heterozygous A870G (OR = 1.72, 95% CI 1.10 - 2.68, P = 0.017). The subjects at least having one CCND1 870A allele had OR of 2.40(95% CI 1.59 -3.63, P < 0.001). Furthermore, smoking may increase the risk of developing NPC interacting with CCND1 G870A polymorphism. Kaplan-Meier analysis and Cox regression analysis demonstrated that the five-year survival rate of subjects with A.A, AG and GG genotypo was 56.2%, 78.5% and 81.4% (AA vs GG, P=0.003; AA vs AG, P =0.012; AG vs GG, P =0.132), but not independent prognostic factor in NPC(P = 0.501). Conclusions The CCND1 870A allele is associated with the NPC in Han population in Yunnan China, meanwhile, showed a significant prognosis for those patients.
