Therapeutic efficacy of combined treatment with surgical decompression and drug for traumatic optic neuropathy
10.3760/cma.j.issn.1673-0860.2009.02.012
- VernacularTitle:手术联合药物治疗外伤性视神经病的疗效分析
- Author:
Guang-Gang SHI
1
;
Zhao-Di WANG
;
Guo-Liang MAO
;
Ling SHEN
;
Shi-Guo YANG
Author Information
1. 山东大学附属省立医院
- Keywords:
Optic nerve injuries;
Otorhinolaryngologic surgical procedures;
Drug therapy
- From:
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
2009;44(2):126-129
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the therapeutic efficacy of combined treatment with surgical decompression and drug for traumatic optic neuropathy (TON) and analyze the influential factors. Methods A retrospective study on 69 patients (70 eyes) with TON treated with optic canal decompression through transnasal endoscopic approach and drug was conducted. The visualacuity was divided into 5 grades:no light perception (NLP), light perception (LP), hand move, count finger, >0.02, marked as Ⅰ-Ⅴ respectively. Of 40 eyes with grade Ⅰ, 18 eyes received emergency operation for severe optic canal fracture confirmed by CT;22 eyes received corticesteroid therapy firstly and then operation. Of 30 eyes above grade Ⅰ, 16 eyes with optic canal fracture confirmed by CT received emergency operation;14 eyes received corticosteroid therapy firstly and 3 days later received operation. Postoperative follow-up lasted 3-12 months to observe the recovery of visual acuity. Results The therapeutic efficacy of patients with the visual acuity of LP and above LP was better than that of NLP (90.0% to 27.5%), the difference had statistical significance (χ2=26.98,P<0.001). In operated group, the therapeutic efficacy in patients whose visual acuity was improved from NLP after glucocorticoid therapy (80.0%) was better than that of the patients with no improvement (5.9%), the difference had statistical significance (χ2=12.09,P<0.001). Conclusion The imaging findings of optic canal fracture can not be used as determinants for operation. The patients with NLP whose visual acuity had no improvement after corticosteroid therapy are poor candidates for surgical decompression. The visual acuity before treatment is the main factor affecting the therapeutic efficacy.
