Relationship between the expression of hypoxia-inducible factor-1α and epidermal growth factor receptor and micro vessel density and their clinical significance
10.3760/cma.j.issn.1673-0860.2009.06.009
- VernacularTitle:喉癌组织中缺氧诱导因子1α和表皮生长因子受体的表达与微血管密度的关系
- Author:
Peng LIN
1
;
Wei WANG
;
Wen-Juan CAI
;
Chun-Rong HAN
;
Yan SUN
;
Man LI
;
Bao-Cun SUN
Author Information
1. 天津市第一中心医院
- Keywords:
Laryngeal neoplasms;
Carcinoma,squamous cell;
Hypoxia-inducible factor 1,alpha subunit;
Receptor,epidermal growth factor;
Receptors,cell surface;
Antigens,CD;
Prognosis
- From:
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
2009;44(6):480-485
- CountryChina
- Language:Chinese
-
Abstract:
Objective Analyze the relationship between the expression of hypoxia-inducible factor-1α( HIF-1α)and epidermal growth factor receptor(EGFR) and CD105 micro vessel density (MVD) and their value in evaluating biologic behavior and prognosis in laryngeal cancer. Methods Ninty-one cases of laryngeal cancer were analyzed about their clinical and pathology data. In tumor tissue the expression of HIF-1α and EGFR was detected by immunohistochemistry and MVD was marked by CD105. Results The expression of HIF-1α was correlated with size, TNM stage, T stage, lymph node metastasis and histological grade( all P < 0. 05). The expression of EGFR was correlated with TNM stage, lymph node metastasis, histological grade and relapse(all P <0. 05). MVD was correlated with type, TNM stage, T stage, lymph node metastasis, metastasis and histological grade ( all P < 0. 05 ). The expression of HIF-1α and EGFR was correlated with MVD ( F value was 7. 644 and 5. 197 respectively, P value was 0. 001and 0. 025 respectively). The correlation between the expression of HIF-1α and EGFR was significant statistically( r = 0.238,P= 0.007). The survival rate of patients of 3 years and 5 years were 56.1% and 44.2% respectively. Survival analysis by Log Rank showed that prognosis of laryngeal cancer patients was correlated with type, TNM stage and the expression of both HIF-1αand EGFR. While Cox multiple factors analysis demonstrated that TNM stage and expression of EGFR were independent prognostic factor of laryngeal cancer. (P value was 0. 049 and 0. 041 respectively,RR was 1. 300 and 2. 417 respectively). Conclusions HIF-1α and EGFR are key molecular event during development and progression of laryngeal cancer, which act in regulating tumor angiogenesis as well, and show intimate relationship with biological behavior and prognosis of laryngeal cancer.
