Dynamic observation of applying repairing laryngeal mucosal defect with heterogenous acellular dermal matrix
10.3760/cma.j.issn.1673-0860.2009.07.009
- VernacularTitle:异种脱细胞真皮基质修复膜修复喉黏膜缺损的临床动态观察
- Author:
Qing-Quan ZHANG
1
;
Yan SUN
;
Xi-Cheng SONG
;
Hua ZHANG
;
Qiang WANG
;
Xi-Wen WANG
;
Yu-Hong ZHU
;
Xiu-Mei CHEN
;
Shao-Hong JIANG
Author Information
1. 青岛大学医学院附属烟台毓璜顶医院
- Keywords:
Laryngeal neoplasms;
Carcinoma,squamous cell;
Reconstructive surgicalprocedures;
Extracellular matrix;
Biological dressings
- From:
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
2009;44(7):561-564
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the clinical effect of heterogeneity (cattle) acellulur deunal matrix in repairing mucosa defect in laryngeal surgery. Methods Eighteen cancer patients with mucosa defect in central vocal area accepted treatment with heterogeneity acellular deunal matrix after surgery. There were two methods to repair mucosa defect. One was simple use of acellular deunal matrix, the second was combined use of acellular deunal matrix and muscle lamella or muscle and tendon film lameUa. 18 cases had cancer in central vocal area: T2N0M0(8), T3N1M0(5), T3N2M0(4), T4N2M0(1). All were squamous cell carcinoma. Ten cancer patients accepted radiation after surgery. The radiotherapy volume was 60 -80 Cry. After the operation, the patients were checked by fibrolaryngoscope four or five times after half a year, observing the dynamic development. Results All 18 patients were healed, rechecked by endoscope after 0. 5 -6 months, heterogeneity acellular deunal matrix mingled with mucosa within 30 -60 d, no allergy and irritation were found. The laryngeal function, including breathing, pronouncing and swallowing, was recovered. The survival rate (1 year) was 100%, and 10 patients survived after 2 years. After radiotherapy, the process of recovery was not affected. Conclusions Heterogeneity acellular deual matrix can be easily obtained and it is a new method to repair mucosa defect. The operative procedure is easy to perform and worthwhile to use clinically.
