Detection of Human Herpesvirus-6 (HHV-6) in Cerebrospinal Fluid of a Patient with Fatal Status Epilepticus.
- Author:
Sung Min CHO
1
;
Jeong Sook SONG
;
Eun Kyeong KANG
Author Information
1. Department of Pediatrics, Dongguk University Ilsan Hospital, Goyang, Korea. smchoped@hotmail.com
- Publication Type:Case Report
- Keywords:
Human herpesvirus-6;
Encephalitis;
Status epilepticus;
Brain death
- MeSH:
Brain Death;
Diarrhea;
DNA;
Encephalitis;
Extremities;
Fever;
Herpesvirus 6, Human;
Hospitalization;
Humans;
Infant;
Lorazepam;
Midazolam;
Phenobarbital;
Phenytoin;
Polymerase Chain Reaction;
Seizures;
Status Epilepticus;
Unconscious (Psychology)
- From:
Journal of the Korean Child Neurology Society
2012;20(3):196-200
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Human herpesvirus-6 (HHV-6) often causes mild illnesses, but is rarely associated with encephalitis or other fatal neurological conditions. We report a girl who died of a intractable status epilepticus from HHV-6. A 14-month-old girl presented with focal motor seizures in right extremities evolving to generalized convulsive status epilepticus. She had a history of mild diarrhea for 4 days and high fever for 2 days. Although she was treated with lorazepam, phenytoin, phenobarbital, and continuous midazolam infusion, generalized seizures continued for 3 hours after arrival. She became seizure free, but remained unconscious and ended up to death at the 44 days of hospitalization. The CSF HHV-6 DNA PCR turned out to be positive.
