Investigation on the incidence of diabetes in chronic hepatitis C patients and their HCV genotypes.
- Author:
Ping ZHAO
1
;
Jiang-bin WANG
;
Jian JIAO
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Aged; China; epidemiology; Diabetes Mellitus, Type 2; complications; epidemiology; Female; Genotype; Hepacivirus; genetics; Hepatitis C, Chronic; complications; virology; Humans; Incidence; Male; Middle Aged
- From: Chinese Journal of Hepatology 2006;14(2):86-88
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the incidence of type 2 diabetes mellitus in patients with chronic hepatitis C (CHC) and its relation to HCV genotypes, and to confirm whether diabetes is an exohepatic manifestation of CHC.
METHODSSandwich hybridization microplate assays and fluorescence quantification PCR technology were used to detect HBV DNA, HCV RNA and HCV genotypes of 308 chronic hepatitis C patients and 305 chronic hepatitis B patients. The incidence of diabetes in these patients was compared and analyzed with that in 310 controls.
RESULTSThe incidence of diabetes in patients with chronic hepatitis C was 32.79%, higher than that in patients with chronic hepatitis B (9.84%) and in the control group (8.39%). Serum levels of ALT and TBIL in hepatitis C patients with diabetes were higher than those without diabetes. Infection rate of HCV 1b in hepatitis C patients with diabetes was the highest (40.59%), and when compared with that of those without diabetes the difference was very significant.
CONCLUSIONIncidence of diabetes mellitus in patients with chronic hepatitis C is high, especially those infected with HCV 1b, and the liver functions of these patients are more severely damaged.
