Effect of TCM treatment according to syndrome differentiation in enhancing curative effect and reducing side-effect of madopa.
- Author:
Xin-Fu LIAN
1
;
Xiao-Dong LUO
Author Information
- Publication Type:Journal Article
- MeSH: Aged; Aged, 80 and over; Benserazide; adverse effects; therapeutic use; Diagnosis, Differential; Dopamine Agents; adverse effects; therapeutic use; Drug Combinations; Drug Synergism; Drug Therapy, Combination; Drug-Related Side Effects and Adverse Reactions; etiology; prevention & control; Drugs, Chinese Herbal; therapeutic use; Female; Humans; Levodopa; adverse effects; therapeutic use; Male; Medicine, Chinese Traditional; Middle Aged; Parkinson Disease; diagnosis; drug therapy; Phytotherapy; Prospective Studies; Syndrome; Treatment Outcome
- From: Chinese Journal of Integrated Traditional and Western Medicine 2007;27(9):796-799
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the effect of TCM treatment according to syndrome differentiation in en-hancing curative effect and reducing side-effect of madopa in patients with Parkinson' s disease (PD).
METHODSThe trial was conducted in 101 PD patients with a prospective stratified randomized and controlled method. They were assigned to group 1 in which the patients of rigidity were treated with Pabing Recipe 1 (PR1) plus Madopa tablets, group 2 with those of tremor given Pabing Recipe 3 (PR3) plus Madopa tablets, and group 3 given a fixed Chinese recipe plus Madopa tablets as the control. The treatment course for all the groups was 3 months. Clinical efficacy was evaluated with unified Parkinson's disease rating scale (UPDRS) and the adverse reactions observed before and after treatment.
RESULTSAfter treatment, the 4 partial scores and the total score of UPDRS decreased significantly in group 2 (P<0.01), and the former of them and the total score declined in group 1 and 3 (P<0.01), the improvement was better in group 1 and 2 than that in group 3 (P<0.01); the improvement rate in group 1 to 3 was 95.5%, 100.0% and 83.7%, respectively, which was significantly higher in group 1 and 2 than that in group 3 (P<0.05).
CONCLUSIONTCM treatment according to syndrome differentiation could improve the clinical symptoms and reduce complications in PD patients, which could enhance curative effect and reduce side-effect of madopa.
