Effect of Bnxia Xexin Decoction and its disassembled recipes on somatostatin in rats with stress gastric ulcer.
- Author:
Zhong ZHANG
1
;
Yin-chu SI
;
Li-min BAI
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Anti-Ulcer Agents; therapeutic use; Immunohistochemistry; Male; Phytotherapy; Plant Extracts; chemistry; therapeutic use; Random Allocation; Rats; Rats, Wistar; Somatostatin; biosynthesis; Stomach Ulcer; drug therapy; etiology; metabolism; Stress, Psychological; complications
- From: Chinese Journal of Integrated Traditional and Western Medicine 2007;27(10):916-918
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the acting mechanism of Banxia Xiexin Decoction (BXD) and its disassembled recipes on stress gastric ulcer, for providing references to the scientific researches on the assembling rule of BXD.
METHODSThe rat model of acute gastric ulcer was established by water immersion-restraint stress. The experimental rats were divided into the normal group, the model group and the treated groups treated with BXD and its disassembled recipes respectively to observe the therapeutic efficacy and the changes of somatostatin (SS) expression in brain and gastric tissues.
RESULTSIn the model group, the SS expression was 0.0237 +/- 0.0056 in brain and 0.0171 +/- 0.0053 in gastric tissue respectively, which was significantly lower than those in the normal group (0.0305 +/- 0.0024 and 0.0282 +/- 0.0037) respectively. Compared to the model group, the two indexes in rats treated with full BXD were 0.0294 +/- 0.0050 and 0.0288 +/- 0.0027, treated with sweet flavor portion were 0.0314 +/- 0.0027 and 0.0219 +/- 0.0059, all showed increase of SS expression, and the increment was more significant in the former.
CONCLUSIONBXD can increase the expression of SS to realize its therapeutic efficacy, and the recipe was assembled rationally.
