Clinical study on effect of Erzhi Tiangui Granule in improving the quality of oocytes and leukemia inhibitory factor in follicular fluid of women undergoing in vitro fertilization and embryo transfer.
- Author:
Fang LIAN
1
;
Yi-li TENG
;
Jian-wei ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Drugs, Chinese Herbal; therapeutic use; Embryo Transfer; Female; Fertilization in Vitro; methods; Follicle Stimulating Hormone; therapeutic use; Follicular Fluid; metabolism; Humans; Infertility, Female; drug therapy; Leukemia Inhibitory Factor; metabolism; Medicine, Chinese Traditional; Oocytes; cytology; Phytotherapy; Yang Deficiency; drug therapy
- From: Chinese Journal of Integrated Traditional and Western Medicine 2007;27(11):976-979
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effects of Erzhi Tiangui Granule (ETG) on the concentration of leukemia inhibitory factor (LIF) in follicular fluid (FF) and quality of oocytes/embryos after in vitro fertilization and embryo transfer (IVF-ET).
METHODSWomen undergoing IVF-ET were randomly assigned to two groups: the treated group (42 cases) treated with ETG combined with Western medicine and the control group (38 cases) treated with Western medicine alone. Syndrome of Shen-deficiency, amount of oocytes, rates of mature oocytes, fertilization, cleavage, high-quality embryos and pregnancy, as well as LIF level in FF were observed and compared between the two groups. The relationship of LIF level with mature oocyte rate and high-quality embryo rate was analyzed, respectively.
RESULTSIn the treated group after treatment, the syndrome of Shen-deficiency and the above-mentioned indexes tested were improved better than those in the control group, respectively. Correlation analysis showed that the LIF level in FF was positively correlated with the rate of mature oocyte, high-quality embryo and the outcome of pregnancy.
CONCLUSIONETG can distinctively increase the amount of oocyte, elevate the quality of embryo and raise the successful rate of IVF-ET. The mechanism maybe correlated to the increase of LIF level in FF and the activating of microenvironment for its full expression.