Expression of proline-rich tyrosine kinase-2 in human primary colorectal carcinoma and its prognostic implication.
- Author:
Zong-nai ZHANG
1
;
Xin WANG
;
Ting LI
;
Hong-fang YIN
;
Yuan-lian WAN
;
Yu-cun LIU
;
Jing ZHU
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Aged, 80 and over; Colorectal Neoplasms; enzymology; pathology; Female; Focal Adhesion Kinase 2; metabolism; Humans; Male; Middle Aged; Prognosis
- From: Chinese Journal of Surgery 2008;46(6):440-442
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the expression of proline-rich tyrosine kinase-2 (Pyk2) in human primary colorectal carcinoma (CRC) and it's prognostic significance.
METHODSThe expression of Pyk2 was retrospectively examined with immunohistochemistry (IHC) in 108 tissues of primary CRC. The correlation of Pyk2 expression to prognosis and relevant clinical factors were analyzed.
RESULTSThe rate of Pyk2 low-expression in CRC was 56.5% (61/108). The expression of Pyk2 correlated significantly to the histological grade (P < 0.05) and the TNM stage (P < 0.05), while no correlation between Pyk2 expression and age, tumor size (P > 0.05). Patients with Pyk2 over-expression had significantly higher 5-year survival rate (66.0%) than those with Pyk2 low-expression (31.4%). Pyk2 expression, together with carcinoma histologic grade and TNM stage were prognostic factors to CRC on the multivariate analysis.
CONCLUSIONSPyk2 expression can be a prognostic factor to the CRC patients together with other predictors.
