Clinical related factors of portal vein tumor thrombosis in patients with hepatocellular carcinoma: a logistic regression analysis.
- Author:
Wen-Ping LÜ
1
;
Jia-Hong DONG
;
Zhi-Qiang HUANG
;
Shuang SHI
;
De-Yu GUO
;
You-Sheng LIU
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Aged; Aged, 80 and over; Carcinoma, Hepatocellular; pathology; Child; Embolism; etiology; Female; Follow-Up Studies; Humans; Liver Neoplasms; pathology; Logistic Models; Male; Middle Aged; Portal Vein; Retrospective Studies; Risk Factors
- From: Chinese Journal of Surgery 2008;46(10):733-736
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the related factors of portal vein tumor thrombosis (PVTT) in patients with HCC.
METHODSA total number of 234 patients with hepatocellular carcinoma (HCC) were included in this retrospective study. Uni-variate and multi-variate logistic regression analysis were employed to analyze the association between PVTT and 18 routine clinical parameters.
RESULTSAmong the 234 patients with HCC, 15% of patients (35/235) had PVTT. Univariate logistic regression analysis revealed significant association of age (P = 0.016), gamma glutamyl transferase (GGT, P = 0.003), number of segmental invasion (P = 0.007), microvascular invasion (P < 0.01), segment location of S2 (P = 0.001), S3 (P = 0.000), S4 (P = 0.004) and S6 (P = 0.016). Multivariate analysis shows potential significant predictors of PVTT in HCC were age (RR: 0.373; 95% CI: 0.146-0.954; P = 0.040), the tumor location of S3 (RR: 4.625; 95% CI: 1.916-11. 165;P = 0.001), GGT (RR: 4.091; 95% CI: 1.448-11.553; P = 0.008) and microvascular invasion (RR: 20.912; 95% CI: 4.745-92.172; P < 0.01).
CONCLUSIONSPVTT occurred more commonly in the younger (< 50 years old), and those with high level of GGT, segment location of S3 and microvascular invasion.
