Gene expression difference analysis between abdominal aorta aneurysm and normal abdominal artery.
- Author:
Hai-Guang ZHAO
1
;
Shi-Jun FU
;
Mi-Er JIANG
Author Information
- Publication Type:Journal Article
- MeSH: Aorta, Abdominal; metabolism; Aortic Aneurysm, Abdominal; genetics; Gene Expression Profiling; Humans; Oligonucleotide Array Sequence Analysis
- From: Chinese Journal of Surgery 2008;46(9):691-693
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo identify gene expression differences between abdominal aorta aneurysm (AAA) and normal abdominal artery.
METHODSFive AAA specimens and five normal abdominal artery specimens were collected. Total RNA was extracted and purified from the samples independently. Then isolated RNA was labeled and hybridized onto the Affymetrix Genechip.
RESULTSOne thousand nine hundreds and sixty-two differently expressed genes were identified in AAA compared with normal abdominal artery, of which 554 genes were up-regulated and 1408 genes were down-regulated. Functional analysis revealed that genes involved in immune response, inflammatory response and chemokines were significantly up-regulated in AAA.
CONCLUSIONThe differently expressed genes may be useful in providing new insights and foster a better understanding of the mechanism of AAA.
