Protective effect of enalaprilat injection against early postburn organ damage in rats.
- Author:
Bing-Qian ZHANG
1
;
Guang WANG
;
Jiong-Yu HU
;
Jia-Ping ZHANG
;
Yue-Sheng HUANG
Author Information
- Publication Type:Journal Article
- MeSH: Angiotensin-Converting Enzyme Inhibitors; therapeutic use; Animals; Burns; blood; drug therapy; pathology; Disease Models, Animal; Dose-Response Relationship, Drug; Enalaprilat; therapeutic use; Female; Male; Random Allocation; Rats; Rats, Sprague-Dawley; Viscera; drug effects; pathology
- From: Chinese Journal of Surgery 2008;46(13):1014-1017
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the dose-effect relationship of enalaprilat (ENA) injection on the organ damage following early burn injury in rats.
METHODSA total of 54 SD rats were subjected to 30% total body surface area III scald injury, and were randomly divided into simple scald group (B group, with conventional fluid transfusion after scald), ENA treated group (E1, E2, E3 group, with intraperitoneal enalaprilat injection of 1, 2, 4 mg/kg after scald respectively). Other 6 rats were taken as normal control. Aortic systolic pressure (AOSP), aortic diastolic blood pressure (AODP), mean arterial pressure (MAP), angiotensin 1, blood urea nitrogen (Bun), creatinine (Cr), creatinine kinase (CK), alanine aminotransferase (ALT), aspartate aminotransferase (AST) of the simple scald group, E1 group, E2 group and E3 group were investigated at 6 h and 12 h post burn.
RESULTSAng II, Bun, Cr, CK, ALT, AST levels in ENA treated group after 6 h and 12 hours were significantly lower than those of simple scald group (all P < 0.05). AOSP, AODP, MAP in ENA treated group after 6 and 12 hours were significantly higher than those of simple scald group (all P < 0.05).
CONCLUSIONLow-dose enalaprilat, injection (1 mg/kg) could alleviate organ damage in post-burned rats, but has little effect on AOSP and AODP.
