Linkage disequilibrium study of microsatellite markers on chromosome 6 and schizophrenia.
- Author:
Hong DENG
1
;
Xiehe LIU
;
Guiqing CAI
;
Henry TERWEDOW
;
Zhaoxi WANG
;
Xin XU
Author Information
- Publication Type:Journal Article
- MeSH: Age of Onset; Chromosomes, Human, Pair 6; Humans; Linkage Disequilibrium; Microsatellite Repeats; genetics; Schizophrenia; genetics
- From: Chinese Journal of Medical Genetics 2002;19(1):6-9
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the relationship between the microsatellite markers on chromosome 6 and schizophrenia by linkage disequilibrium analysis.
METHODSTwenty-eight microsatellite markers on chromosome 6 were evaluated in 115 affected-sib-pair and trios families. Linkage disequilibrium analysis was conducted according to diagnostic categories, Positive and Negative Syndrome Scale (PANSS) and other clinical data by XDT and MAPMAKER/SIBS software system.
RESULTSSignificant P value (P<0.005) was found in all the four diagnostic categories. Only the locus of D6S1960 showed positive P value (P<0.05) in all the subgroups divided by PANSS scale and the age of onset.
CONCLUSIONThe area around D6S1960 in short arm of chromosome 6 may contain susceptibility gene of schizophrenia.
