Homozygous deletion of p16 and p15 genes in laryngeal squamous cell carcinoma.
- Author:
Fucai LI
1
;
Ning KANG
;
Yinghui LI
;
Guang HE
;
Changkun LIN
;
Xinghe SUN
;
Hongming GAO
;
Kailai SUN
Author Information
- Publication Type:Journal Article
- MeSH: Carcinoma, Squamous Cell; genetics; Cell Cycle Proteins; Cyclin-Dependent Kinase Inhibitor p15; Cyclin-Dependent Kinase Inhibitor p16; genetics; Gene Deletion; Genetic Markers; Genetic Predisposition to Disease; Homozygote; Humans; Introns; genetics; Laryngeal Neoplasms; genetics; Polymerase Chain Reaction; methods; Transcription Factors; genetics; Tumor Suppressor Proteins
- From: Chinese Journal of Medical Genetics 2002;19(1):30-32
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo assess the relationship of homozygous deletion status of p16 (MTS1/INK4a/CDKN2A), p15(MTS2/INK4b/CDKN2B) genes and laryngeal squamous cell carcinoma(LSCC) progression.
METHODSDNA was extracted from fresh tumors. Homozygous deletion of p16 exon 2(p16E2) in 80 cases of LSCC and p15 exon 2(p15E2) in 67 cases of LSCC were detected by the polymerase chain reaction technique.
RESULTSThe p16E2 deletion rate in 80 cases was 12.5%(10/80); the p15E2 deletion rate in 67 cases was 11.94%(8/67); the p16E2 and p15E2 codeletion rate in 67 cases was 5.97%(4/67).
CONCLUSIONHomozygous deletion of p16E2 and p15E2 is related with LSCC oncogenesis, and it may play a role to some extent in LSCC malignant progression.
