A preliminary study of pentanucleotide repeat polymorphism of apolipoprotein(a) gene in coronary atherosclerotic heart disease.
- Author:
Bo HU
1
;
Xin ZHOU
;
Lin LI
;
Xi LI
Author Information
- Publication Type:Journal Article
- MeSH: Aged; Apolipoproteins; genetics; Apoprotein(a); Asian Continental Ancestry Group; genetics; Coronary Artery Disease; genetics; Coronary Disease; genetics; Electrophoresis, Polyacrylamide Gel; methods; Female; Gene Frequency; Humans; Lipoprotein(a); genetics; Male; Microsatellite Repeats; genetics; Middle Aged; Oligonucleotides; genetics; Polymerase Chain Reaction; methods; Polymorphism, Genetic
- From: Chinese Journal of Medical Genetics 2002;19(1):46-48
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVEThis study inquired into the relationship between a pentanucleotide repeats(PNR) polymorphism of the apolipoprotein(a)[apo(a)] gene and coronary atherosclerotic heart disease(CHD) in Chinese Han nationality.
METHODSPNR polymorphism of the apo(a) gene from 165 cases of CHD and 153 normal individuals were analyzed by polymerase chain reaction(PCR)-denature polyacrylamide gel electrophoresis-silver stain.
RESULTSThe frequencies of (TTTTA)(5/8) genotype (0.188) and (TTTTA)(5) allele (0.115) in CHD group were remarkably higher than those in control group (0.039, 0.026)(P<0.01, P<0.05).
CONCLUSIONThese findings indicate that the PNR polymorphism of apo(a) is associated with the susceptibility to CHD, which may be involved in the development of CHD.
