Comparative study of HLA-DQA1 and HLA-DRB1 allele in patients with endometriosis and adenomyosis.
- Author:
Lili ZONG
1
;
Dejing PAN
;
Weiming CHEN
;
Yuanli HE
;
Zehuan LIU
;
Jianghai LIN
;
Anlong XU
Author Information
- Publication Type:Journal Article
- MeSH: Asian Continental Ancestry Group; genetics; Endometriosis; genetics; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; HLA-DQ Antigens; genetics; HLA-DQ alpha-Chains; HLA-DR Antigens; genetics; HLA-DRB1 Chains; Humans; Polymerase Chain Reaction; methods
- From: Chinese Journal of Medical Genetics 2002;19(1):49-51
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo make a comparative study of HLA-DQA1 and HLA-DRB1 allele frequencies in the cases of endometriosis and adeonmyosis.
METHODSThe allelic types of HLA-DQA1 and HLA-DRB1 were detected by polymerase chain reaction-sequence specific primers (PCR-SSP) technique in 51 cases of endometriosis, 45 cases of adenomyosis, and 44 normal individuals as the control.
RESULTSThe frequencies of HLA-DQA1*0401(7.8%, 10.0%) were significantly increased in the endometriosis group and the adenomyosis group (Pc=0.03, Pc=0.01), and the frequencies of HLA-DQA1*0301(8.8%, 5.6%) were significantly decreased in these two groups (Pc=0.00, Pc=0.00).There was no significant difference between the frequencies of HLA-DQA1 and HLA-DRB1 of endometriosis and adenomyosis.
CONCLUSIONThe results indicate that HLA-DQA1*0301 and *0401 alleles are associated with both endometriosis and adenomyosis, and there is perhaps common mechanism involved in both endometriosis and adenomyosis based on HLA-DQA1 and HLA-DRB1 allele frequencies.
