Cytochrome P450 2C19 gene polymorphism in four Chinese nationality populations.
- Author:
Song ZHANG
1
;
Zhaowen DONG
;
Li TANG
;
Qiang ZHOU
;
Zhanpeng WU
Author Information
- Publication Type:Journal Article
- MeSH: African Continental Ancestry Group; genetics; Aryl Hydrocarbon Hydroxylases; Asian Continental Ancestry Group; genetics; China; ethnology; Cytochrome P-450 CYP2C19; Cytochrome P-450 Enzyme System; genetics; European Continental Ancestry Group; genetics; Gene Frequency; Genetics, Population; Humans; Mixed Function Oxygenases; genetics; Polymerase Chain Reaction; methods; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length
- From: Chinese Journal of Medical Genetics 2002;19(1):52-54
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the cytochrome P450 2C19(CYP2C19) gene polymorphism in 4 Chinese nationality populations.
METHODSThe genotypes of the unrelated Miao, Buyi, Tu and Dulong subjects were analyzed by polymerase chain reaction and restriction fragment length polymorphism (RFLP).
RESULTSCYP2C19*2 allele frequencies were 0.291, 0.329, 0.315 and 0.349 in Miao, Buyi, Tu and Dulong population, respectively. The four populations were consistent with Hardy-Weinberg expectations (P>0.05).
CONCLUSIONThe frequencies of CYP2C19*2 were in agreement with those of other published data on Asian, but were different from those data on European and African.
