Genetic polymorphism of D16S539, D7S820 and D13S317 loci in the Kazak ethnic population.
- Author:
Xueling CHEN
1
;
Chen HUANG
;
Yukang YUAN
;
Riming LIU
;
Jian XU
;
Tusheng SONG
;
Shengbin LI
Author Information
- Publication Type:Journal Article
- MeSH: China; ethnology; European Continental Ancestry Group; genetics; Female; Gene Frequency; Genetics, Population; Genotype; Humans; Male; Polymorphism, Genetic; Tandem Repeat Sequences; genetics
- From: Chinese Journal of Medical Genetics 2002;19(1):55-57
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo analyze the genetic polymorphism of D16S539, D7S820 and D13S317 in Chinese Kazak ethnic population from Xinjiang.
METHODSOne hundred and two unrelated individuals and a sample of families (n=42) were investigated by multiplex amplification, 6% denaturing PAGE and silver staining. And, the obtained allele frequencies were compared with those of other populations.
RESULTSEight, seven, eight alleles were observed at the 3 STR loci respectively and the genotypes distributions were in accordance with Hardy-Weinberg equilibrium. The expected heterozygosities for these loci were 0.9439, 0.9356 and 0.9304; the calculated polymorphism formation content (PIC) was 0.9905; the discrimination power (DP), 0.9998; the paternity exclusion (PE), 0.9572. In addition, significant difference was found in comparison with other populations, and in the sample of families (n=42) no new mutations could be found.
CONCLUSIONThe multiplex examination of 3 STR loci can be used in forensic identification and population genetics research.
