Analyses of genetic model of psoriasis vulgaris.
- Author:
Xuejun ZHANG
1
;
Hongyan WANG
;
Shanyu CHEN
;
Fuxi WANG
;
Taofeng LIU
;
Zaixing WANG
;
Ming LI
;
Sen YANG
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Aged; Child; Child, Preschool; Data Interpretation, Statistical; Family Health; Female; Humans; Male; Middle Aged; Models, Genetic; Psoriasis; genetics
- From: Chinese Journal of Medical Genetics 2002;19(2):108-111
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the possible genetic model of psoriasis vulgaris.
METHODSThe complex segregation analysis and heritability calculation were performed with the aid of Penrose method, Falconer regression method and SAGE-REGTL program.
RESULTSIt was found that in 1043 patients with psoriasis vulgaris, 305 patients (29.24%) have the family history of psoriasis, and 738 patients have not the family history. A ratio of s/q approached 1/(square root of q) with Penrose method, and the heritability values of psoriasis in the first-degree and second-degree relatives were 67.04%, 46.6% respectively. By complex segregation analysis, Mendelian, non-major-gene model and environment model were rejected for psoriasis.
CONCLUSIONThe results suggest that psoriasis follows a pattern of polygenetic or multifactorial inheritance rather than single-gene inheritance.
