Two single nucleotide polymorphisms of beta 2-adrenoceptor gene in elderly patients with hypertension.
- Author:
Hong WU
1
;
Xiufeng SONG
;
Junhua XIAO
;
Fang HU
;
Wei HUANG
;
Daru LU
;
Jinglun XUE
;
Li JIN
Author Information
- Publication Type:Journal Article
- MeSH: Aged; Aged, 80 and over; Alleles; DNA; genetics; Female; Gene Frequency; Genotype; Humans; Hypertension; genetics; Male; Middle Aged; Polymorphism, Single Nucleotide; genetics; Receptors, Adrenergic, beta-2; genetics
- From: Chinese Journal of Medical Genetics 2002;19(2):127-129
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the association of two single nucleotide polymorphisms (SNPs) of beta 2-adrenoceptor (beta 2-AR) gene with hypertension in elderly patients.
METHODSThe study samples were collected from unrelated Chinese Han population of Dabie Mountain in Anhui province. Eighty-six elderly patients with hypertension and 43 controls were selected. Genotypes of +1053 and +1239 SNPs were typed by polymerase chain reaction-restriction fragment length polymorphism.
RESULTSThe frequencies of the two SNPs complied well with the Hardy-Weinberg equilibrium in normal group. The distribution of genotypes AA, GA,GG of the SNP at locus +1239 in moderate and severe hypertension group was significantly different from that in normal group (chi square=8.67, P<0.05). There were evident differences in the frequencies of alleles of the two groups (chi square=4.02, P<0.05). No significant difference was observed in the distribution of genotypes of the SNP at locus +1053 between the two groups.
CONCLUSIONThese data indicate that the SNP at locus +1239 of beta 2-AR gene is associated with hypertension in elderly patients.
