Influence of angiotensin II type 1 receptor gene polymorphism on patients with essential hypertension complicated by brain infarction.
- Author:
Ya ZHONG
1
;
Daiwen HA
Author Information
- Publication Type:Journal Article
- MeSH: Aged; Alleles; Brain Infarction; complications; Female; Gene Frequency; Humans; Hypertension; blood; complications; genetics; Lipids; blood; Male; Middle Aged; Polymorphism, Genetic; Receptor, Angiotensin, Type 1; Receptors, Angiotensin; genetics
- From: Chinese Journal of Medical Genetics 2002;19(3):201-204
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo identify the A1166/C polymorphism of angiotensin II type 1 receptor (AT1R) gene in patients with essential hypertension complicated with brain infarction (BI).
METHODSAT1R genotyping with polymerase chain reaction-restrictive fragment length polymorphism was performed in 70 normotensive subjects, 72 hypertensive patients without cardio-cerebrovascular diseases(EH-NCCVD) and 70 hypertensive patients with BI. The relationship between the polymorphism of AT1R gene and plasma lipid levels was also studied.
RESULTSThe frequencies of C allele in the two groups of hypertension were higher than that in the health controls, respectively (P<0.05). But there was no significant difference in the frequency of C allele between the two groups of hypertension. A positive correlation was observed between the lipoprotein(a) and AT1R gene A1166/C polymorphism in hypertensive patients.
CONCLUSIONAT1R gene contributes to the development of essential hypertensive, but not to the incidence of BI in the hypertensive.
