A linkage analysis of quantitative trait loci for familial schizophrenia on chromosome 1.
- Author:
Guiqing CAI
1
;
Xinyao WU
;
Tao LI
;
David A COLLIER
;
Xiehe LIU
;
Bingjian FENG
;
Hong DENG
;
Dayue TONG
;
Jianjin LI
;
Jinghua OU
Author Information
- Publication Type:Journal Article
- MeSH: Chromosomes, Human, Pair 1; genetics; Family Health; Genetic Linkage; Humans; Lod Score; Microsatellite Repeats; Quantitative Trait, Heritable; Schizophrenia; genetics
- From: Chinese Journal of Medical Genetics 2002;19(4):281-284
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the molecular genetic relationship between chromosome 1 and quantitative trait loci for familial schizophrenia.
METHODSA series of assessment scales included positive and negative syndrome scale (PANSS), global assessment of functional scale (GAFS), premorbid schizoid and schizotypal traits scale (PSST), premorbid social adjustment scale (PSA) were applied to quantify the phenotypes of schizophrenia. Non-parametric linkage analysis of quantitative traits was conducted in 32 multiplex pedigrees with schizophrenia by using 29 microsatellite makers on chromosome 1.
RESULTSHaseman-Elston quantitative trait analysis detected a maximum Traditional H-E Lods of 1.73 and a maximum EH H-E Lods of 1.65 of negative symptoms (PANSS-N ) at 147.64 cM, which was overlapped to the positive region of 1q21-23 in qualitative linkage analysis.
CONCLUSIONThe results suggest there might be an independent quantitative trait locus of negative symptoms on 1q21-23 for familial schizophrenia.
