A study of the relationship between MICA gene and systemic lupus erythematosus.
- Author:
Guihong BAN
1
;
Jiayou CHU
;
Changzhi MAO
;
Zhaoqing YANG
;
Shaobin XU
;
Zhengtao CHU
;
Xiaoqin HUANG
;
Sizhong ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Alleles; China; DNA; genetics; Female; Gene Frequency; Genotype; Histocompatibility Antigens Class I; genetics; Humans; Lupus Erythematosus, Systemic; genetics; Male; Polymorphism, Single-Stranded Conformational
- From: Chinese Journal of Medical Genetics 2002;19(4):298-301
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the relationship between major histocompatibility complex class I chain-related A(MICA) gene and systemic lupus erythematosus (SLE).
METHODSThe alleles and frequencies of exons 4 and 5 of MICA gene were determined in 70 cases of SLE and 152 controls of Yunnan Hans by STR genotyping, polymerase chain reaction, single strand conformation polymorphism and bidirection DNA sequencing.
RESULTSFive alleles of exon 5 and 10 alleles of exon 4 were found in this study. The frequency of each allele was determined in patients and controls. There was no significant difference between the two groups in exons 4 and 5 of MICA gene.
CONCLUSIONExons 4 and 5 of MICA were not related to SLE in Yunnan Hans.
