Association of HLA-DQB1 alleles and dermatomyositis/ polymyositis.
- Author:
Xiuping HAN
1
;
Ning ZHAI
;
Qingrui ZHANG
;
Jiuhong LI
;
Jifeng LIU
;
Juan DU
;
Fangji SONG
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Aged; Alleles; Child; Dermatomyositis; genetics; Female; Gene Frequency; HLA-DQ Antigens; genetics; HLA-DQ beta-Chains; Humans; Male; Middle Aged
- From: Chinese Journal of Medical Genetics 2002;19(4):322-323
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate further the nature of HLA-DQB1 alleles association with dermatomyositis/polymyositis (DM/PM).
METHODSHLA-DQB1 typing of 52 patients with DM/PM were investigated by polymerase chain reaction-sequence specific primer method, and the frequencies of HLA-DQB1 alleles were compared.
RESULTSIt was found that the patients with DM/PM had significantly increased frequency of HLA-DQB1*0401(RR=3.56, P=1.79 10(-3), Pc<0.05).
CONCLUSIONThe results suggest that HLA-DQB1*0401 gene contribute to genetic susceptibility to DM/PM.
