Genetic polymorphisms, function and clinical effect of HLA-G.
- Author:
Haiying MENG
1
;
Yiping HOU
Author Information
1. School of Forensic and Pre-clinical Medicine, Sichuan University, Chengdu, Sichuan, 610041 P.R.China. forensic@mail.sc.cninfo.net
- Publication Type:Journal Article
- MeSH:
Alleles;
HLA Antigens;
genetics;
immunology;
HLA-G Antigens;
Histocompatibility Antigens Class I;
genetics;
immunology;
Humans;
Immune Tolerance;
immunology;
Killer Cells, Natural;
immunology;
Polymorphism, Genetic;
T-Lymphocytes, Cytotoxic;
Trophoblasts;
immunology
- From:
Chinese Journal of Medical Genetics
2002;19(4):350-353
- CountryChina
- Language:Chinese
-
Abstract:
HLA-G is a non-classical major histocompatibility complex class I molecule that differs from the classical HLA I class molecules by (1) a limited polymorphism, (2) a tissue-restricted distribution and (3) a transcription of spliced messenger RNAs encoding for at least four membrane-bound and two soluble HLA-G isoforms. Extensive studies over the past few years have identified HLA-G as a molecule involved in immune tolerance. In this review, attempts were made to summarize the current state of knowledge of the polymorphisms, expression, function, the effects of HLA-G on immuno-associated disease, evolution of HLA-G and its utility in disease therapy.
