Pathological characteristics and clinical significance of macrochilia secondary to venular malformation.

Author: Wei WANG ¹ ; Xiao-xi LIN ; Gang MA ; Wei LI ; Xiao-jie HU ; Hui CHEN
Author Information

1. Department of Plastic and Reconstructive Surgery, Ninth People's Hospital, Shanghai Jiao Tong University, Shanghai 200011, China.
Publication Type:Journal Article
MeSH: Adolescent; Adult; Female; Hamartoma; etiology; pathology; Humans; Lip; abnormalities; pathology; Lip Diseases; etiology; pathology; Male; Microvessels; pathology; Middle Aged; Port-Wine Stain; complications; pathology; Young Adult
From: Chinese Journal of Stomatology 2010;45(4):211-213
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo analyze the histologic characteristics of macrochilia secondary to port-wine stain and to elucidate the possible mechanism.
METHODSTwenty-one cases of macrochilia secondary to venular malformation were included and the histology of the lesions was observed by light microscope.
RESULTSHistological examination revealed vascular abnormalities and a number of widely distributed hamartomatous changes in macrochilia secondary to venular malformation. The average vessel diameter is (39.8 +/- 15.7) microm. The degree of hamartomatous change: mild (1 case), moderate (7 cases) and severe (13 cases).
CONCLUSIONSThe complex hamartomatous changes suggest a genetically determined, multilineage developmental field defect in the pathogenesis of venular malformation.