Association between preterm low birth weight and maternal cytokine levels of saliva and gingival crevicular fluid
10.3760/cma.j.issn.1002-0098.2010.05.002
- VernacularTitle:母体唾液及龈沟液细胞因子水平与早产低体重新生儿关系的病例对照研究
- Author:
Zhen HUANG
1
;
Yue-Qin SHA
;
Jun RANG
;
Zhi-Bin CHEN
;
Jiang-Xia MIAO
;
Yu-Yan SUN
Author Information
1. 北京大学口腔医学院口腔医院
- Keywords:
Saliva;
Interleukins;
Periodontitis;
Preterm low birth weight infant
- From:
Chinese Journal of Stomatology
2010;45(5):260-264
- CountryChina
- Language:Chinese
-
Abstract:
Objective To examine the hypothesis that periodontitis was one of the sources of inflammation in preterm low birth weight (PLBW) mothers and investigate the relationship between PLBW and inflammatory factors.Methods The samples of saliva and gingival crevicular fluid (GCF) were collected from 83 PLBW mothers(PLBW group) and 44 normal birth weight(NBW) mothers(NBW group).The levels of IL-1β and IL-6 were analyzed by enzyme-linked immunosorbent assay.The concentrations of cytokines in saliva and GCF were compared between the two groups.Results IL-1β level in saliva of PLBW group was higher than which of NBW group significantly[(78.32±11.81) ng/L vs.(39.66±11.89) ng/L, P<0.05].There was no statistically significant difference on IL-6 level in saliva[(17.45±3.13) ng/L vs.(16.28±0.66) ng/L], IL-1β level in GCF[(93.58±13.22) ng/L vs.(81.38±9.28) ng/L]and IL-6 level in GCF[(15.35±0.28) ng/L vs.(14.87 ±0.37) ng/L) between two groups, but those of PLBW group were higher than NBW group.Significant negative correlations existed between gestational age at delivery and probing depth.It was also found significant negative correlations between gestational age at delivery and IL-6(r =-0.274, P<0.01), between the weight of the new bom infants and IL-6 levels in saliva(r =-0.424, P<0.01), IL-1β level in GCF(r =-0.231, P<0.01).Conclusions There was a tendency presenting the higher inflammatory cytokine in GCF and saliva, the shorter gestation period and the lower birth weight The levels of cytokine in saliva and GCF were higher in PLBW mothers.The correlation may be exist between maternal periodontitis and PLBW.
