Levels of tumor necrosis factor-α and interleukin-β in saliva of metabolic syndrome patients
10.3760/cma.j.issn.1002-0098.2010.05.004
- VernacularTitle:代谢综合征患者与健康者唾液中肿瘤坏死因子α、白细胞介素1β水平比较
- Author:
Lu HE
1
;
Peng LI
;
Yue-Qin SHA
;
Zhi-Bin CHEN
;
Qing-Xian LUAN
;
Xing-Yu WANG
Author Information
1. 北京大学口腔医学院口腔医院
- Keywords:
Periodontitis;
Saliva;
Cytokines;
Metabolic syndrome
- From:
Chinese Journal of Stomatology
2010;45(5):269-273
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association between periodontitis and the low-grade inflammation in metabolic syndrome(MS) patients.Methods Fifty-seven MS patients, 26 healthy controls were enrolled.Non-stimulated whole saliva was collected.The levels of tumor necrosis factor (TNF)-α and interleukin (IL)-1 β was analyzed by radioimmunoassay and enzyme-linked immunosorbent assay, respectively.Concentration of cytokines was compared between MS patients and the healthy controls.Correlations between the cytokines and various periodontal indices, and between the cytokines level and different quantity of metabolic syndrome components were also investigated.Results Levels of TNF-α in saliva of MS patients[(69.30 ±21.01) ng/L]were significantly higher than that in the healthy subjects[(57.85±15.69) ng/L,P<0.05], and of IL-1β in MS patients[(616.42±360.05) ng/L]higher than that in healthy subjects[(506.06±245.76) ng/L], but the difference was not statistically significant TNF-α was positively correlated with bleeding index(BI).In MS patients, TNF-α level and IL-1β level increased with increasing severity of periodontal disease and increasing component numbers of MS.Conclusions Periodontal inflammation may be one of the sources of low-grade inflammation in MS patients.Both systemic and periodontal conditions may influence the level of salivary TNF-α and IL-1β.
