Expression of E-cadherin and β-catenin in oral squamous cell carcinomas of tongue: correlation with the clinicopathologic features and patient prognosis
10.3760/cma.j.issn.1002-0098.2010.05.011
- VernacularTitle:上皮钙黏蛋白与β-连环素在舌鳞状细胞癌中的表达及其与预后的关系
- Author:
Rui ZHU
1
;
Xiao-Yun JIANG
;
Xiao-Ling SONG
;
Wei ZHANG
;
Sheng CHEN
;
Lai-Kui LIU
Author Information
1. 无锡市口腔医院
- Keywords:
Carcinoma,squamous cell;
Cadherins;
Beta catenin
- From:
Chinese Journal of Stomatology
2010;45(5):295-298
- CountryChina
- Language:Chinese
-
Abstract:
Objective To examine the E-cadherin and β-eatenin expression in oral squamous cell carcinoma of tongue (OSCCT) and investigate the relationship of these markers with clinicopathologic features and patient prognosis.Methods Quantitative immunohistochemistry analysis was used to examine E-cadherin and β-catenin expression in lesions of 30 OSCCT patients.The relationship between the expression of E-cadherin and β-catenin and clinicopathologicical features was analyzed.Results The decreased expression of E-cadherin was observed in 19 of 30 (63%) tumours from patients who eventually developed a recurrent tumour and was also associated with recurrence (P = 0.007).The expression of E-cadherin was associated with survival (P = 0.018) and an independent prognostic factor in univariate analysis.There was no correlation between the expression level of E-cadherin and sex, age, histological differentiation, tumour size, clinical stage, or lymph node metastasis.The high expression of β-catenin was observed in 18 of 30 (60%) tumours.No correlation between β-catenin expression and clinicopathological features was observed.Conclusions The absence or reduced expression of E-cadherin was closely associated with recurrence and survival in OSCCT patients.The aberrant expression of E-cadherin may provide a useful prognostic marker in OSCCT.
