Experimental study on influence of acupuncture and moxibustion therapy on apoptosis of colonic epithelial cells in rats of ulcerative colitis.
- Author:
Huan-gan WU
1
;
Zhen HUANG
;
Hui-rong LIU
;
Wei ZHANG
;
Yin SHI
;
Yi ZHU
;
Yun-hua CUI
;
Shi-Min LIU
Author Information
- Publication Type:Journal Article
- MeSH: Acupuncture Points; Animals; Apoptosis; Colitis, Ulcerative; therapy; Epithelial Cells; Humans; Moxibustion; Rats; Rats, Sprague-Dawley
- From: Chinese Acupuncture & Moxibustion 2005;25(2):119-122
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the mechanism of acupuncture and moxibustion in adjusting apoptosis of colonic epithelial cells of the rat of ulcerative colitis (UC).
METHODSUC rats were randomly divided into four groups including normal control group (NC), model control group (MC), herbs-partitioned moxibustion group (HPM) and electroacupuncture group (EA). The HPM and EA groups were respectively treated with herbs-partitioned moxibustion and electroacupuncture at "Qihai" (CV 6) and bilateral "Tianshu" (ST 25). Then the colon of the rat was taken and the changes of the tissue structure and the cell apoptosis were observed by electron microscope and flow cytometer respectively.
RESULTSThe colon tissue showed histopathological changes, and apoptosis of epithelial cells increased in the model mice of UC as compared with the normal rat. Electroacupuncture and drug-separated moxibustion could significantly decrease the abnormal apoptosis of epithelial cells.
CONCLUSIONThe adjustment of the abnormal apoptosis of epithelial cells is one of the mechanisms of drug-separated moxibustion and electroacupuncture treating UC.
