Related substances in orlistat detected with UPLC-MS/MS.
- Author:
Ting-Ting ZHANG
;
Chen MA
- Publication Type:Journal Article
- MeSH:
Anti-Obesity Agents;
analysis;
chemistry;
Chromatography, High Pressure Liquid;
Drug Contamination;
Lactones;
analysis;
chemistry;
Quality Control;
Spectrometry, Mass, Electrospray Ionization;
Tandem Mass Spectrometry
- From:
Acta Pharmaceutica Sinica
2014;49(3):380-384
- CountryChina
- Language:Chinese
-
Abstract:
The study aims to identify related substances in orlistat pharmaceutical substance from different production technologies. Advanced technologies including UPLC-QTOF-MS and UPLC-QTrap-MS were used and the structures or molecules of 10 kinds of related substances in orlistat were identified. The experimental data were valuable to the quality control and development of orlistat.
