Research progresses of pharmacokinetics of polysaccharides.
- Author:
Yang YI
;
Hong-Xun WANG
;
Jing-Ren HE
- Publication Type:Journal Article
- MeSH:
Administration, Oral;
Animals;
Injections;
Intestinal Absorption;
Metabolic Clearance Rate;
Molecular Weight;
Polysaccharides;
administration & dosage;
analysis;
pharmacokinetics;
urine;
Tissue Distribution
- From:
Acta Pharmaceutica Sinica
2014;49(4):443-449
- CountryChina
- Language:Chinese
-
Abstract:
Pharmacokinetic analysis has attracted more and more attentions in the research field of bioactive natural product. However, there is limited study on the pharmacokinetics of polysaccharides. This paper focused on the research progresses of pharmacokinetics of polysaccharide, summarized the applications of chromatography, isotope labeling method, spectrophotometry, fluorospectrophotometry and biological assay in the analysis of polysaccharide pharmacokinetics, elucidated the behaviors of absorption, distribution, degradation and excretion of polysaccharide in experimental animals, and revealed the effects of physicochemical characteristic, administration dose and route on the pharmacokinetic properties of polysaccharide, which could be served as a reference for the related works.
