Advances in the study of aldehyde oxidases.
- Author:
Jia-Qi MI
;
Yan LI
- Publication Type:Journal Article
- MeSH:
Aldehyde Oxidase;
antagonists & inhibitors;
chemistry;
metabolism;
Animals;
Drug Discovery;
Humans;
Liver;
enzymology;
Oxidation-Reduction;
Pharmaceutical Preparations;
metabolism;
Raloxifene Hydrochloride;
pharmacology;
Substrate Specificity;
Xenobiotics;
chemistry;
metabolism
- From:
Acta Pharmaceutica Sinica
2014;49(5):582-589
- CountryChina
- Language:Chinese
-
Abstract:
Aldehyde oxidase (AOX), a highly conserved molybdoflavoenzyme in mammal cytoplasm, has broad substrate specificity and ability to catalyze the oxidation of aldehydes and nitrogen, oxygen-containing heterocyclic rings. AOX was found to widely distribute with the individual differences in vivo and plays an important role in phase I metabolism of drugs and xenobiotics. The biological characteristics of AOX and its contributions in drug metabolism are introduced briefly in this review.
