Rosiglitazone improves learning and memory impairment of 3 x Tg mice.
- Author:
Jin-Zhi SONG
;
Jie SUN
;
Duo-Chen JIN
;
Yan-Qiu DENG
- Publication Type:Journal Article
- MeSH:
Alzheimer Disease;
Amyloid beta-Peptides;
Animals;
Brain;
drug effects;
Disease Models, Animal;
Glycosylation;
Learning;
drug effects;
Memory;
drug effects;
Memory Disorders;
drug therapy;
Mice;
Mice, Transgenic;
Neurofilament Proteins;
metabolism;
Phosphorylation;
Thiazolidinediones;
pharmacology;
tau Proteins;
metabolism
- From:
Acta Pharmaceutica Sinica
2014;49(6):807-812
- CountryChina
- Language:Chinese
-
Abstract:
This study is to investigate the protective effect of rosiglitazone (RSG) against learning and memory impairment of APP/PS1/tau transgenic mice. AD mice model was replicated by using 6-month APP/PS1/tau transgenic mice. The learning and memory ability of mice was evaluated by Morris water maze and Western blotting assays was applied to measure the phosphorylation and O-glycosylation of Tau and neurofilaments (NFs) protein. The results demonstrated that RSG could reverse the learning and memory deficits of 3 x Tg mice significantly. It was also found that RSG could suppress the hyperphosphorylation of Tau and NFs protein levels and increase the glycosylation expression of Tau and NFs proteins in 3 x Tg mice brain. Together, RSG ameliorates cognitive impairments of 3 x Tg mice via the alleviation of the hyperphosphorylated Tau and NFs proteins burden in the brain.
