MicroRNA and multiple myeloma.
- Author:
Chun-Ming LI
1
;
Li-Juan CHEN
;
Jian-Yong LI
Author Information
1. Department of Hematology, Nanjing Medical University First Hospital, Nanjing 210029, Jiangsu Province, China.
- Publication Type:Journal Article
- MeSH:
Humans;
MicroRNAs;
Multiple Myeloma;
genetics
- From:
Journal of Experimental Hematology
2011;19(1):244-248
- CountryChina
- Language:Chinese
-
Abstract:
MicroRNA (miRNA) represents a new class of endogenous, non-coding small RNA molecules that functions as gene regulator. They can repress the expression of target genes at the post-transcriptional level by base pairing to the 3'-untranslated region of the respective target mRNAs. miRNA plays important roles in the regulation of cell proliferation, metabolism, apoptosis and differentiation. The dysregulation of miRNA expression contributes to tumorigenesis. This review summarizes recent progress of research on the characteristics and function of miRNA, as well as the role of miRNA in multiple myeloma development, abnormal karyotype in chromosomes and drug-resistant.
