Expression of XIAP gene in chronic myeloid leukemia and its clinical significance.
- Author:
Shu-Guo WANG
1
;
Hong-Zai GUAN
Author Information
1. Department of Clinical Laboratory Examination, Qingdao Municipal Hospital, Qindao, Shandong Province, China.
- Publication Type:Journal Article
- MeSH:
Adult;
Case-Control Studies;
Female;
Gene Expression;
Humans;
Leukemia, Myelogenous, Chronic, BCR-ABL Positive;
genetics;
pathology;
Male;
Prognosis;
X-Linked Inhibitor of Apoptosis Protein;
genetics
- From:
Journal of Experimental Hematology
2011;19(2):321-323
- CountryChina
- Language:Chinese
-
Abstract:
This study was purpose to investigate the expression of XIAP mRNA in chronic myeloid leukemia (CML) and to explore its significance in the advance and prognosis of CML. The chromosomal karyotype analysis and detection of XIAP mRNA were performed by the technique of chromosomal R banding and real time PCR in 71 patients with CML and 10 healthy controls. The results showed that there was a significant increase of XIAP mRNA expression in accelerated and blastic phase of the CML, compared with the patients in chronic phase (t = 9.10, 9.30, p < 0.01). Moreover, the difference of XIAP mRNA expression level was not statistically significant in different karyotype groups. It is concluded that the XIAP gene expression in accelerated and blastic phases of CML patients obviously increases, XIAP gene is closely related to the advance of CML.
