Effects of alendronate on structural properties of trabecular bone in dogs.
- Author:
Hu JIANHUA
1
;
Zhang LIANG
;
Zhao LILIAN
;
Huang GONGYI
Author Information
- Publication Type:Journal Article
- MeSH: Alendronate; pharmacology; Animals; Anisotropy; Biometry; methods; Bone Density; Bone and Bones; anatomy & histology; drug effects; Dogs; Female; Lumbar Vertebrae; anatomy & histology; drug effects
- From: Chinese Medical Sciences Journal 2002;17(4):210-214
- CountryChina
- Language:English
-
Abstract:
OBJECTIVETo evaluate the effects of alendronate on the structural properties of trabecular bone.
METHODSAlendronate was administered at a daily p.o. dose of 0.5 mg/kg over a 12-week period in hound dogs (n = 8 for both the control and treated group), and the structural indices of the lumbar vertebral (L1 and L2) trabecular bone were assessed directly from 3-D images.
RESULTSTreatment with alendronate increased bone volume fraction by 9.5% and 7.7% in L1 and L2 respectively. Trabecular thickness significantly increased after alendronate treatment, whereas trabecular separation remained constant. The degree of anisotropy for the alendronate-treated group was decreased compared with that of the control group. Bone surface to volume ratio declined significantly in the alendronate-treated group, whereas alendronate induced a higher bone surface density.
CONCLUSIONAlendronate increased the structural properties of canine trabecular bone after short-term treatment at a dose of 0.5 mg x k(-1) x day(-1).
